Insulin resistance in obesity is thought to be mediated via non-esterified fatty acids (NEFA) and proinflammatory factors including tumor-necrosis-factor-alpha (TNF-α), interleukin-6 (IL-6) and monocyte chemoattractant protein-1 (MCP-1) [17]. This evidence concerns the gene TNF and obesity due to melanocortin 4 receptor deficiency.