These SNPs were also significantly associated with the bivariate outcomes of cortical cataract and performance on several neuropsychological tests including the BNT, LMI, LMD and TMTB which are strongly associated with future AD risk [44]–[46] evaluated at the same time as the MRI scan, suggesting that variants in CTNND2 may influence functional as well as structural brain changes. This evidence concerns the gene CTNND2 and Alzheimer disease.