Our association findings for CTNND2 with bivariate outcomes including cognitive function are consistent with results from a recent GWAS in a prospectively followed cohort showing near genome-wide significance for association of rate of cognitive decline with rs2973488 [58], a CTNND2 SNP located 2 kb distal of rs13189742 which was strongly associated with the CC-THV bivariate outcome (Table S5). Here, CTNND2 is linked to Mental deterioration.