The enforced expression in the IL-2Rβ−/− KO mice of a transgenic chimeric receptor—composed of the extracellular domain of wild-type IL-2Rβ fused to the cytoplasmic domain of the IL-7Rα—rescued the IL-2Rβ−/− KO mice from autoimmunity. Here, IL2RB is linked to Autoimmunity.