DNMT1 and cancer: We also observed comparable Dnmt1 protein levels by Western blot or in DNMT1 RNA levels by Exon array in pancreatic CAFs and cancer cell lines (data not shown), suggesting that the limited number of genes induced by 5-aza-dC was not due to a lack of DNMT1 expression in CAFs or a lack of Dnmt1 inhibition by 5-aza-dC.