DNMT3A and cancer: The mechanisms responsible for these aberrant methylation patterns in cancers are not well understood, but suspected mechanisms include overexpression of DNMT1, accumulation of DNA methylation alterations with age [5], [6] and environmental influences [7], altered activity of the de novo methylating enzymes DNMT3a and DNMT3b[8], [9], and possibly from altered cellular microenvironment such as from chronic inflammation [3], [10].