LAP3 and neurodegenerative disease: Since protein homeostasis in the mitochondria is a balance between non-selective degradation by processes such as autophagy and selective degradation by peptidases and ATP-dependent proteases, the development of an orthogonal mitochondria-specific DD may be challenging, but also highly valuable given the importance of mitochondrial proteins in pathologic process such as aging and neurodegenerative diseases [28].