These data are in line with observations in HCC, in which GADD45β induction by sorafenib occurred only in sensitive hepatocellular carcinoma cell lines, independent of the Raf/MEK/ERK signaling pathway [34].These findings confirm our definition of sensitive cell lines, in which sorafenib induces apoptosis and inhibits proliferation. This evidence concerns the gene GADD45B and hepatocellular carcinoma.