VEGFA and wet macular degeneration: In ophthalmology, currently two VEGF-antagonistic drugs are approved for the treatment of wet age-related macular degeneration (wet AMD) worldwide: ranibizumab, a Fab antibody fragment binding the most relevant splice variants of VEGF-A [8, 9], and pegaptanib, a PEGylated aptamer that binds the heparin-binding domain of VEGF-A [10].