Aside from the previously validated AD endophenotype-related genes TOMM40, CR1 and APOE (Biffi et al., 2010; Lambert et al., 2009; Shen et al., 2010), other genes occurring in the top 10 ranking pathways, include ADCY2, ACTN1, ACACA and GNAI1, all of which have been associated with AD related changes in hippocampal gene expression (Ravetti et al., 2010; Taguchi et al., 2005, supporting information). This evidence concerns the gene APOE and Alzheimer disease.