Genomic features such as mutational status of immunoglobulin heavy chain variable region genes (IGHV), ataxia telangiectasia mutated (ATM) and TP53 tumor suppressor genes, β2-microglobulin, zeta-chain-associated protein kinase 70 (ZAP70) expression, interphase cytogenetics, and complex karyotype on metaphase cytogenetics, provide further differentiation of disease prognosis [2]. Here, ATM is linked to neoplasm.