Overall, and in the context of understanding mechanistic details of CD30hi lymphomagenesis, our results provide direct ex vivo-derived support in a natural animal model for the in vitro results in other species, which propose that ligand-independent and -dependent CD30 signaling-induced constitutive activation of NF-κB is a mechanism of neoplastic transformation in Hodgkin’s disease antigen over-expressing lymphomas[17]. The gene discussed is TNFRSF8; the disease is lymphoma.