CD4 and Menkes disease: Similarly, in MD, a recent study has shown interactions between vIL-8 (a chemotactic factor) and peripheral CD4 + CD25+ T cells (closely resemble T–reg phenotype)[12,133], and suggested that vIL-8 may enhance the recruitment of T-reg cells to the MDV lymphoma microenvironment, which would further induce immunosuppression and enhance lymphomagenesis, supporting our previous observations[6,12].