TNFRSF8 and lymphoma: A similar phenomenon has been observed in the CD30 over-expressing human cutaneous lymphoproliferative disease lymphomatoid papulosis[4,125]: allelic differences in the CD30 transcription are due to polymorphisms in the human CD30 microsatellite repressor element (located −1.2 kb and −336 bp of the CD30 promoter) and are associated with disease progression to lymphoma[125].