CST3 and cardiovascular disorder: A positive association was also found between serum cystatin C levels and the Gensini score independent of eGFR, even after adjustment for established risk factors associated with cardiovascular disease and cystatin C. Similar results were also reported by Niccoli et al. [31], who demonstrated that the independent association between cystatin C and CAD severity was superior to that of creatinine or eGFR.