To our surprise, the immunophenotype (CD21-, CD35, S100-, SMA focal +, ALK-) overthrows the diagnosis of FDC tumor, IPT and IMT, so we reviewed this case carefully and found some scattered adipocytes and thick-walled blood vessels at the boundaries between the tumor and surrounding liver tissues (As shown in Figure. The gene discussed is ALK; the disease is inflammatory myofibroblastic tumor.