PNPLA3 and Hepatic steatosis: A single genetic variant, I148M, entailing a change from isoleucine (I) to methionine (M) at position 148 in the human patatin-like phospholipase domain containing 3 gene (PNPLA3, Adiponutrin) on chromosome 22 has been widely associated with increased hepatic steatosis [7-11].