Using data from the eIF2A alignment (Figure 7A) and LIG_eIF4E_1, we performed a SLiMSearch (23) analysis of YxPPx[ILMVA][KR] instances in the human proteome: all highly significant hits (Sigmotif <0.001) occur in messenger RNA (mRNA) translation-related proteins (Table 2), with the exception of carnitine deficiency-associated gene expressed in ventricle 3 (CDV3), which has no known function. Here, CDV3 is linked to hyperinsulinemic hypoglycemia, familial, 4.