PTEN and ovarian carcinoma: According to genetic and pathologic features, epithelial ovarian cancer are classified in Type I tumors, characterized by a variety of somatic mutations or amplification/deletion of oncogenes or oncosuppressors including K-RAS, B-RAF and PTEN, and Type II tumors, which are chromosomally unstable, and present with mutated or deleted TP53 (in more than 80% of the cases) and BRCA inactivation (in up to 30% of the cases)[53,54].