For instance, miR-30a, which negatively regulates the expression of Beclin 1[37], was found down-regulated in samples from relapsing patients diagnosed with stage I ovarian cancer[85]; and miR-101, which represses the expression of the autophagy protein Atg4[39], was found down-regulated in ovarian cancer compared to normal tissue[86]. Here, BECN1 is linked to ovarian cancer.