Mutational ras protein can affect cell proliferation, cell cycle regulation and anti-apoptotic signal by decreasing the activity of endogenous GTPase, or transcriptional decreasing the expression of Fas receptor and regulating the last time of the p38 activity of Jun N-terminal protein kinase (JNK) by Ral-GEF (Ras related GTPase-guanine exchange factor) pathway [29] Meanwhile, N-ras has different function to the generation of cancer in different individuals[30-32]. This evidence concerns the gene MAPK8 and cancer.