CASP8 and Familial prostate cancer: Gene arrays followed by western analysis of PC3 cell and tumor lysates treated with simvastatin identified several genes involved in the extrinsic death-receptor apoptosis pathway modulated by simvastatin, but not with docetaxel, such as tumor necrosis factor (TNF), Fas-L, Traf1 and cleaved caspase 8, along with other genes such as Lhx4, Nme5 and Trp53inp1, which are novel, yet unknown regulators of cell survival and apoptosis in prostate cancer cells.