Tumor necrosis factor (TNF), TNF-related apoptosis inducing ligand (TRAIL), Fas-ligand (Fas-L), TNF-related factor-1 and 2 (Traf1/2) etc. are some of the key molecules that belong to the extrinsic pathway or death receptor signaling that are known to be de-regulated in cancers [8,9]. This evidence concerns the gene TNFSF10 and cancer.