Eventhough a synergistic effect on the protein expression of Bcl-2 and Bcl-xL was seen in prostate cancer cells with combined treatment of simvastatin and docetaxel, a net significant additive effect on the final products of intrinsic pathway such as cleaved caspase 3 and cleaved caspase 9 was not observed (Figure 2A and B). This evidence concerns the gene CASP3 and Familial prostate cancer.