Massive parallel next-generation sequencing of six cases of WT GIST (five pediatric and one young adult) revealed that the GIST from the young adult patient (22 year-old man, with multinodular gastric lesions and multiple liver metastases) carried a C to T transition at nucleotide 206 in SDHA exon 2, a nonsense mutation resulting in the replacement of arginine with a stop codon at residue 31 of SDHA, causing truncation of the peptide chain at residue 30 (p.Arg31X) (Figure 1). The gene discussed is SDHA; the disease is gastrointestinal stromal tumor.