L1CAM and glioma: This result was unexpected because in numerous non-neural tumors including gliomas, glioblastomas, and neuroendocrine tumors, L1CAM had been found to stimulate proliferation and aggressiveness (Suzuki et al. 2005; Siesser and Maness 2009; Schafer and Altevogt 2010; Cheng et al. 2011).