As demonstrated in Figure 4, patients suffering from severe sepsis without treatment of DAA revealed significantly higher serum concentrations of leptin compared to healthy controls (n = 45, mean = 12116 pg/ml, ± SEM = 1945 pg/ml) (leptin concentrations, Day 1: DAA-, mean = 30175 pg/ml, ±SEM = 4203 pg/ml. This evidence concerns the gene LEP and Sepsis.