ANXA5 and neoplasm: In a mouse model of tumor vaccination, annexin A5 has been shown to impair the uptake of irradiated apoptotic lymphoma cells by macrophages and to specifically target them to CD8α+ DCs, thus inducing the release of proinflammatory cytokines and tumor-specific immune memory, which contributed to the regression of growing tumors and conferred resistance against tumor re-challenge (Bondanza et al., 2004).