Various anti-tumor mechanisms have been reported to be exerted by IFN-γ, including inhibition of tumor cell proliferation, apoptosis induction, inhibition of angiogenesis, and an overall enhancement of tumor immunogenicity as characterized by an upregulation of the MHC-I pathway, modulation/extension of the MHC-I ligandome, and downregulation of NKG2D ligands (Dunn et al., 2006; Reits et al., 2006; Lugade et al., 2008). The gene discussed is KLRK1; the disease is neoplasm.