IFNA1 and systemic lupus erythematosus: Hence, interfering with DNase II activity, which in phagocytes mediates the proper degradation of engulfed prey cell DNA, could represent a promising strategy to stimulate the described IFN cascade required for the induction of productive immune responses and well-known for its crucial role in the etiopathogenesis of autoimmune diseases, such as SLE (Kawane et al., 2006; Marshak-Rothstein, 2006; Deng and Tsao, 2010).