In vitro, cancer cells added to blood or plasma promote coagulation in a TF- and phosphatidylserine (PS)-dependent manner, and the coagulation kinetics are strongly dependent upon the number of cancer cells tested (Berny-Lang et al., 2011; Tormoen et al., 2011; Yates et al., 2011; Welsh et al., 2012). The gene discussed is TF; the disease is cancer.