Studies with the HDI MS-275 showed an average IC50 in the nanomolar range (100 nM to 1 μM) in ES cells accompanied by de-repression of the EWS-FLI1 target TGFβRII, re-expression of the histone acetylation sensitive locus p21 and a dose-dependent decrease in tumor volume in MS-275-treated mice (Jaboin et al., 2002). Here, EWSR1 is linked to neoplasm.