PRKAG2 and ischemic cardiomyopathy: However, a close form of inherited cardiomyopathy has been linked to the PRKAG2 gene, a master regulator of glucose and lipid metabolism (Gollob et al. 2001), and one of the major causes of dilated cardiomyopathy, the most common type of cardiomyopathy, is hypertension and ischemic cardiomyopathy (Hunt et al. 2005).