When this region is searched vs. a transcription factor binding site database (TRANSFAC), two conserved binding motifs were detected: an OCT4 binding site, implicated in control of pleuripotent stem cell embryogenesis (Wang and Dai 2010), and an IRF1 binding site, implicated in induction of interferon, tumor suppression, cell-cycle control, and apoptosis (Romeo et al. 2002). Here, POU5F1 is linked to neoplasm.