Although the biofunctional role of P-cadherin in tumour progression is far from being fully elucidated, several in vitro studies using human breast [92, 94] and pancreatic [95] cancer cell lines have suggested a proinvasive role for this molecule, through its interaction with several signalling molecules, such as Rho GTPases and p120ctn [94, 95]. Here, CDH3 is linked to cancer.