Even more surprisingly, when Iqgap2 −/− mice were crossed with Iqgap1 −/− mice [31], the resultant Iqgap1 −/−/Iqgap2 −/− mice showed a lower incidence and smaller size of HCC tumors, and improvement of overall survival compared to Iqgap2 −/− mice [27]. This evidence concerns the gene IQGAP2 and hepatocellular carcinoma.