IQGAP1 and hepatocellular carcinoma: Immunohistochemical analysis of a cohort of HCC patient liver specimens showed that IQGAP2 protein expression was reduced in 78% of the samples (64/82) and, consistent with the Iqgap2 −/− mouse model, the IQGAP1 protein was overexpressed in 84% of tumors studied [43], thus confirming the relevance of the Iqgap2 −/− mouse model to human disease.