According to a proposed model, IQGAP2 plays the role of a tumor suppressor by being a part of the APC/AXIN/GSK3β complex, binding cytoplasmic β-catenin and preventing it from dephosphorylation and, subsequently, from activating β-catenin's nuclear target genes (Figure 2). The gene discussed is IQGAP2; the disease is neoplasm.