APC and neoplasm: The tumor suppressor APC has been the first component of Wnt signalling to be associated to the mitotic spindle, and this is required for proper chromosome segregation: therefore, Apc loss was shown to lead to chromosomal instability [23, 24], and can also induce polyploidy ([25], this is of interest for the physiologically polyploid liver, reviewed by Gentric et al., in this issue).