Neonatal lupus erythematosus (NLE) refers to a clinical spectrum of cutaneous, cardiac, and systemic abnormalities observed in newborn infants whose mothers have autoantibodies against Ro/SSA, La/SSB, and, less commonly, U1-ribonucleoprotein (U1-RNP) [1–3]. This evidence concerns the gene TRIM21 and neonatal lupus erythematosus.