The antibodies associated with heart block and with cutaneous disease are believed to be different; antibodies against the 52/60-kD Ro/SSA and 48-kD La/SSB ribonucleoproteins are associated with heart block, whereas antibodies against the 50-kD La/SSB ribonucleoprotein are associated with cutaneous disease [12, 13]. The gene discussed is TRIM21; the disease is Heart block.