As such, these mothers of patients suspected of having neonatal lupus erythematosus should be screened for antinuclear, anti-double-stranded DNA, anti-Ro/SSA, anti-La/SSB, and anti-U1-RNP antibodies, irrespective of their symptoms or clinical status [9]. The gene discussed is TRIM21; the disease is neonatal lupus erythematosus.