The expression of TLR in CLL is quite heterogeneous between patients but most cases express TLR1, TLR2, TLR6, TLR10 on the cell surface, and TLR7, TLR8, TLR9 within endosomes55 thus resembling normal mature B lymphocytes.39,40,43 Recently, we have studied the full expression profile of mRNA for TLR and signaling molecules in a large group of chronic lymphocytic leukemia (CLL) patients to search for potential differences in specific subsets of patients. The gene discussed is TLR6; the disease is B-cell chronic lymphocytic leukemia.