TLR6 variants were found to be important in different B cell lymphomas including CLL;63 the TLR2-16933T>A variant was associated with a decreased risk of CLL;64 two TLR10-TLR1-TLR6 variants in moderate linkage disequilibrium were significantly associated with Non Hodgkin Lymphoma including CLL cases.65 This evidence concerns the gene TLR1 and B-cell chronic lymphocytic leukemia.