Different responses were also identified in subsets with stereotyped BCR.79 The distinct patterns of TLR/NOD2 functional activity in cells from CLL subgroups defined by the molecular features of the BCR might prove relevant for elucidating the immune mechanisms underlying the natural history of CLL and for defining subgroups of patients who might benefit from treatment with specific TLR ligands. This evidence concerns the gene NOD2 and B-cell chronic lymphocytic leukemia.