BCR and B-cell chronic lymphocytic leukemia: Chiorazzi’s group were the first to report associations between BCR stereotypy and clinical features for a subset of cases expressing stereotyped IGHV4-39/IGHD6-13/IGHJ5 BCRs (now known as subset #8) who experienced aggressive clinical courses complicated by severe recurrent infections, Richter’s transformation, or the occurrence of second solid tumors.56 Of note, a recent collaborative study from Italy independently reported that this particular BCR stereotype is associated with the highest risk for Richter’s transformation among all CLL subgroups analyzed.57