TNFRSF8 and anaplastic large cell lymphoma: Mycosis fungoides (MF), which is the most common and indolent form of CTCL, accounts for 50%–60% of CTCL cases [1]; primary cutaneous CD30+ lymphoproliferative disorders, more specifically primary cutaneous anaplastic large cell lymphoma (PC-ALCL) – the second most common CTCL, accounts for circa 30%; and Sézary syndrome, which is an aggressive leukemic variant of CTCL, affects approximately 5% of patients.