Treatment of CCR4+ Mac-1 tumor bearing mice with AAV8-h1567 and human PBMCs resulted in a marked increase in the number of tumor-infiltrating human CD56+ NK cells, suggesting that CD16A which is expressed on human NK cells is involved in this tumor cell killing through it’s interaction with the Fc portion of h1567, a finding that has been experimentally confirmed through Fc mutagenesis studies (data not shown). This evidence concerns the gene CCR4 and neoplasm.