Similarly, the (CD14++CD16+TIE2+) TEM subset of monocytes showed a non-significant tendency to rise in local disease (p = 0.055) with a median frequency of 0.05%, 0.07%, and 0.05% in total blood leukocytes for healthy, local CRC and mCRC collectives, respectively. This evidence concerns the gene TEK and colorectal carcinoma.