Note that under hyperlipidemic conditions, the influence of H3 trimethylation on Pparα was mirrored by other lipid catabolism-related genes, including Lipe, Atf4, Nr5a2, and Cidea, all of which are associated with the pathophysiology of NAFLD. The gene discussed is NR5A2; the disease is metabolic dysfunction-associated steatotic liver disease.