Regarding the actual therapeutics concerning both niches, the highlights are laid on the humanized monoclonal antibody against vascular endothelial growth factor (VEGF)-A, bevacizumab, which was the first antiangiogenic agent to be approved for cancer therapy in patients with metastatic colorectal cancer, nonsquamous non-small-cell lung cancer, and metastatic breast cancer (reviewed in [125]). This evidence concerns the gene VEGFA and cancer.