Depletion of regulatory T cells in Foxp3-DTR mice by DT injection results in an acute autoimmune and inflammatory phenotype characterized by rampant inflammation, T cell activation, splenomegaly, lymphadenopathy, and autoantibody production by day 8 and death starting at day 10 (Kim et al., 2007; Chinen et al., 2010). The gene discussed is FOXP3; the disease is Lymphadenopathy.