In addition, even if the mechanisms of S1PR2 lymphoma suppressor function remain to be elucidated, S1PR2-deficient mice develop tumors displaying histologic and molecular features of GC-derived DLBCL and S1PR2 is aberrantly mutated in 26% of human DLBCL (Cattoretti et al., 2009). Here, S1PR2 is linked to diffuse large B-cell lymphoma.