IL2RA and diabetes mellitus: Although, this may prove difficult as direct and repeated probing of the tissue of interest (skin in GvHD, pancreatic islets in diabetes), we conjecture that mathematical models will become more and more critical to interpret functional changes as measured among accessible peripheral blood mononuclear cell (e.g., IL-2Rα upregulation in an expanded Treg compartment) and extrapolate them to the tissue of relevance.