Persistence of these connecting fibers bypass the AV node and cause ventricular pre-excitation syndromes similar to Wolff-Parkinson-White syndrome (Rentschler et al., 2001) Patients suffering from Wolff-Parkinson-White syndrome showed mutations in the PRKAG2 gene, which encodes the gamma-2 subunit of the AMP-activated protein kinase (Blair et al., 2001; Gollob et al., 2001). Here, PRKAG2 is linked to Wolff-Parkinson-White syndrome.