EDN1 and Hyperglycemia: These include hyperglycaemia [given that diabetes is a known complication of chronic pancreatitis (Nomiyama et al., 2007)], the endothelial cell derived vasoconstrictor endothelin-1 (Jonitz et al., 2009), cyclooxygenase 2 (COX-2, the inducible form of the rate limiting enzyme that converts arachidonic acid to prostaglandin) (Aoki et al., 2007), galectin-1 (a beta-galactoside binding lectin) (Masamune et al., 2006a) and the haemostatic protein fibrinogen (Masamune et al., 2009).