These include celecoxib (Roh et al., 2010), simvastatin (Lee et al., 2005), roflumilast (Martorana et al., 2005), neutrophil elastase inhibitors or neutrophil elastase knockout (Wright et al., 2002; Shapiro et al., 2003), matrix metalloprotease inhibitors (Pemberton et al., 2005), α 1-antitrypsin (Churg et al., 2003; Pemberton et al., 2006), curcumin (Suzuki et al., 2009), and overexpression of CuZnSOD (Foronjy et al., 2006), which all prevent CS-induced inflammation and emphysema. The gene discussed is ELANE; the disease is Cowden syndrome 1.