KCNK2 and ischemia: One intriguing scenario that might reconcile the broad CNS distribution of Trek channels with their modest impact on behavior is that Trek channel activity is low under normal conditions, becoming evident and impactful only under certain circumstances, such as ischemia (Heurteaux et al., 2004; Buckler and Honore, 2005; Caley et al., 2005; Wang et al., 2012).