When all cases fulfilling WHO criteria for severe malaria are considered, two cases of P. vivax infection (case 1: 429 parasites/μl with prostration and mildly impaired consciousness (Blantyre coma score = 4); case 2: 98 parasites/μl (mixed with P. falciparum by PCR), severe anemia (Hb = 1.7 g/dl), and hyperlactemia (lactate = 6.3 mmol/l) were observed in children with SAO genotype. The gene discussed is SLC4A1; the disease is anemia.