Furthermore, p-AKT, p-mTOR, p-4E-BP1, and cyclin D1 expression levels in epithelial ovarian and peritoneal tumors were shown not to be associated with partial/complete tumor responses to Temsirolimus, however cyclin D1 expression seemed to correlate with PFS ≥6 months (Behbakht et al., 2011). This evidence concerns the gene MTOR and neoplasm.