In some studies, results were inconclusive as only a subset of PTEN null breast cancer cell lines were sensitive to PI3K pathway inhibition (She et al., 2008; Lehmann et al., 2011; Sanchez et al., 2011), whilst others found PTEN deficient breast cancer cells to be preferentially resistant to treatment with PI3K (Tanaka et al., 2011), dual PI3K/mTOR (Brachmann et al., 2009), mTOR kinase, and allosteric mTOR inhibitors (Weigelt et al., 2011). The gene discussed is PIK3CA; the disease is breast cancer.