MTOR and neoplasm: Not only expression levels of activated (i.e., phosphorylated) S6K/rpS6 have been found to correlate with response to allosteric mTOR inhibitors, but in phase II study, total S6K expression in baseline SCLC tumor tissue defined by IHC was reported as a potential predictive biomarker for the therapeutic benefit of Everolimus (n = 22; Tarhini et al., 2010).