PTEN and cancer: Recent work in preclinical models has suggested that PTEN deficient cancers may depend on p110β rather than p110α signaling (Jia et al., 2008; Wee et al., 2008; Edgar et al., 2010; Ni et al., 2012), and a p110β isoform specific inhibitor (GSK2636771) is currently being tested in a clinical trial of PTEN deficient malignancies (NCT01458067).