Recently, another secretase-mediated APP-derived catabolite called APP Intra Cellular Domain (AICD) gained relevance in the field appears to be a multifunctional factor affecting several physiological processes likely to contribute to Alzheimer's disease pathology by acting as a transcription factor that controls the expression of a series of proteins involved in control of cell death and Aβ degradation. This evidence concerns the gene APP and early-onset autosomal dominant Alzheimer disease.