In this study, the mean PPD in the HAART-naïve HIV-seropositive subjects with chronic periodontitis was slightly greater than in HIV-seropositive subjects using HAART (r = 0.01); the mean CD4+ T-cell count in the group of HIV-seropositive subjects using HAART was lower than in the group of HIV-seropositive HAART-naïve subjects. This evidence concerns the gene CD4 and chronic periodontitis.