A direct comparison of the involvement of functional Rab proteins for DENV multiplication in Vero cells showed that two DENV-2 strains, NGC and 16681, depend on functional Rab5 for successful infection, but when transport to late endosomes was blocked by the overexpression of a DN mutant of Rab7 the multiplication of DENV-2 16681 was severely reduced whereas DENV-2 NGC was not impaired (Fig. 4A–B). The gene discussed is AGFG1; the disease is infection.