KRIT1 is a gene responsible for Cerebral Cavernous Malformations (CCM), a major cerebrovascular disease, with a prevalence of 0.1%–0.5% in the general population, characterized by abnormal vascular sinusoids that predispose to seizures, focal neurological deficits, and fatal intracerebral hemorrhage [1], [2], [3], [4]. This evidence concerns the gene KRIT1 and famililal cerebral cavernous malformations.