As shown in Fig. 3 (Panel A and B), GDM placenta villi samples have increased Annexin A2 (1.5 fold change), Annexin A5 (1.8 fold change), and 14-3-3 ζ/δ (2.2 fold change) expression, and decreased Rap1A expression (0.5 fold change), compared with NGT placenta villi. The gene discussed is RAP1A; the disease is gestational diabetes.