For example, a glycoform of CD44 known as HCELL (hematopoietic cell E−/L-selectin ligand), a major E-selectin ligand expressed by human colon cancer and hematopoietic stem cells, was found to be reactive to HECA-452 mAb by Western blot [6], [16]. This evidence concerns the gene CD44 and malignant colon neoplasm.